Complex formation of class I transplantation antigens and a viral glycoprotein.
نویسندگان
چکیده
منابع مشابه
Major histocompatibility complex class I antigens and the control of viral infections by natural killer cells.
Natural killer (NK) cells are large, granular cytotoxic lymphocytes which represent a major portion of the lymphocyte infiltrate of infected tissue at early stages of viral infections (35, 37). NK cells become cytolytically activated and proliferate in vivo after exposure either to alpha, beta, or gamma interferon (IFN-a, -b or -g) or interleukin-2 (4, 6–8, 50). The peak in NK cell activation a...
متن کاملCationic lipids direct a viral glycoprotein into the class I major histocompatibility complex antigen-presentation pathway.
Recombinant glycoprotein B (gB) of herpes simplex virus (HSV) was processed and presented by class I major histocompatibility complex (MHC) molecules after delivery into cells by using N-[1-(2,3-dioleoyloxy)propyl]-N,N,N-trimethylammonium methyl sulfate (DOTAP), a commercially available cationic lipid used for DNA transfection. Cells treated with DOTAP-associated gB were susceptible to lysis by...
متن کاملFrequency of Major Histocompatibility Antigens Class I in Mazandaran Province
Background and purpose: Major histocompatibility antigens are the most polymorphic components of the immune system. The purpose of this study was to determine the frequency of human leukocyte antigens (HLA) in a population in Mazandaran province, Iran. Materials and methods: In a cross sectional study, peripheral blood samples were obtained from 550 people in Immunogenetics Research Center af...
متن کاملMajor-histocompatibility-complex class I alleles and antigens in hematopoietic-cell transplantation.
BACKGROUND Successful engraftment of hematopoietic stem cells from unrelated donors is influenced by disparities between the donor and recipient for HLA-A, B, and C alleles. Disparities between HLA sequence polymorphisms that are serologically detectable are termed antigen mismatches, whereas those that can be identified only by DNA-based typing methods are termed allele mismatches. Whether bot...
متن کاملMolecular modeling of an antigenic complex between a viral peptide and a class I major histocompatibility glycoprotein.
Computer simulation of the conformations of short antigenic peptides (5-10 residues) either free or bound to their receptor, the major histocompatibility complex (MHC)-encoded glycoprotein H-2 Ld, was employed to explain experimentally determined differences in the antigenic activities within a set of related peptides. Starting for each sequence from the most probable conformations disclosed by...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1983
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(17)44498-x